DESCRIPTION:

498 differentially expressed genes in Cluster 6 in the Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S6. From table legend: "This analysis was performed (per cluster) without separating male and female samples. Entries that are greyed out have p_val_adj < 0.05. “Avg_diff” is conditionally formatted to indicate up- and down-regulation of expression in cocaine compared to sucrose (red: up-regulated, green: down-regulated and yellow: no difference). The “Names” sheet at the end of file was used to convert GeneIDs to FlybaseIDs and Gene Symbols. p_val: raw p-value from the differential expression analysis for the given gene in the corresponding cluster. avg_diff: the difference in the loge transformed average expression of the given gene in the corresponding cluster (sheet) between the two conditions (cocaine compared to sucrose). Values above 0 indicate up-regulation of expression due to cocaine, and likewise, values below zero represent downregulation of expression due to cocaine. pct.1: percentage of cells expressing the gene in the cluster from the first condition (cocaine). pct.2: percentage of cells expressing the gene in the cluster from the second condition (sucrose). p_val_adj: Benjamini-Hochberg FDR adjusted p-value." Values presented are p-adjusted values. Data available at GEO with accession number GSE152495.

LABEL:

fly cocaine C6

SCORE TYPE:

Q-Value

DATE ADDED:

2021-06-21

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt

TITLE:

The

JOURNAL:

Genome research May 2021, Vol None, pp. None

ABSTRACT:

Whereas the neurological effects of cocaine have been well documented, effects of acute cocaine consumption on genome-wide gene expression across the brain remain largely unexplored. This question cannot be readily addressed in humans but can be approached using the PUBMED: 34035044
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