401 predicted targets of miR-124, which is one of the miRNAs shown to be upregulated in female humans with cocaine use disorder. miRNA expression was determined via qPCR, and predicted targets were determined via gene ontology (GO) analysis. Values presented are "1" for presence. Data taken from Supplementary material 1.
Peripheral blood microRNA levels in females with cocaine use disorder.
Journal of psychiatric research
Vol 114, pp. 48-54
There is growing emphasis in the field of psychiatry on the need to identify candidate biomarkers to aid in diagnosis and clinical management of addictive disorders. MicroRNAs (miRNAs) are small nucleotide sequences with the ability to regulate gene expression at the transcriptomic level. However, the role of miRNAs as potential biomarkers for addiction is still underexplored. Based on translational and clinical findings, we compared the expression levels of microRNA-124 (miR-124), microRNA-181 (miR-181), and microRNA-212 (miR-212) between a group of females with cocaine use disorder (CUD; n = 30) and a group of healthy female controls (HC; n = 20).
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