DESCRIPTION:

18 genes differentially expressed in the nucleus accumbens (NAcc) following morphine self-administration normalized to vehicle self-administration (VhSA) in adult male Lewis rats. Expression levels were measured with RT-qPCR. Values presented are fold-change from Table 1.

LABEL:

Rat NAcc Morphine SA

SCORE TYPE:

Effect

DATE ADDED:

2021-06-09

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Marcos Ucha, Santiago M Coria, Adrián E Núñez, Raquel Santos-Toscano, David Roura-Martínez, Javier Fernández-Ruiz, Alejandro Higuera-Matas, Emilio Ambrosio

TITLE:

Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats.

JOURNAL:

Journal of psychopharmacology (Oxford, England) 07 2019, Vol 33, pp. 882-893

ABSTRACT:

Addiction is a chronic disorder with a high risk of relapse. The neural mechanisms mediating addictions require protein synthesis, which could be relevant for the development of more effective treatments. The mTOR signaling pathway regulates protein synthesis processes that have recently been linked to the development of drug addiction. PUBMED: 30887859
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