DESCRIPTION:

GWAS Celiac disease with 778 European ancestry cases, 1,422 European ancestry controls

LABEL:

GWASCeliac diseasevan Heel DA

SCORE TYPE:

P-Value

DATE ADDED:

2020-09-04

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C

TITLE:

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

JOURNAL:

Nature genetics Jul 2007, Vol 39, pp. 827-9

ABSTRACT:

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. PUBMED: 17558408
Find other GeneSets from this publication