DESCRIPTION:

Genes associated with Behcet's disease compiled from a Deng et al Systematic Review.

LABEL:

Immune Genetics BD

SCORE TYPE:

Binary

DATE ADDED:

2020-08-29

DATE UPDATED:

2021-04-15

SPECIES:

AUTHORS:

Yan Deng, Weifeng Zhu, Xiodong Zhou

TITLE:

mmune Regulatory Genes Are Major Genetic Factors to Behcet Disease: Systematic Review

JOURNAL:

The Open Rheumatology Journal 6 2018, Vol 12, pp. 70-85

ABSTRACT:

Behcet's disease (BD) is a chronic refractory multi-system autoimmune disorder that occurs in a genetically susceptible host. Multiple genetic factors have been identified that may contribute to the pathogenesis of BD. The major genes with polymorphisms associated with BD include HLA-B and -A, CIITA, ERAP1, MICA, IL10, IL12A, IL12RB2, IL23R, MEFV, IRF8, TNFAIP3, REL, TLR4, NOD1,2, CCR1,CCR3, GIMAP1,2,4, KLRC4, STAT4, NCOA5, FOXP3, PSORS1C1, FUT2, UBAC2, SUMO4, ADO-EGR2, CEBPB-PTPN1, and JPKL-CNTN5. These genes encode proteins involved mainly in immune regulation and inflammation, and some in transcription and post-translational modification. A complete view of these BD-associated genes may provide a clue to this complex disease in terms of its pathogenesis and exploring potentially targeted therapies for BD. PUBMED: 30069262
Find other GeneSets from this publication