DESCRIPTION:

This gene set describes genes that are up-regulated by the host transcriptional response to SARS-CoV-2 infection in human adenocarcinomic alveolar basal epithelial (A549) cells. COVID-19 is the disease caused by SARS-CoV-2 virus. We define up-regulated as those genes that show a (log 2 fold change) of >=2. These data are from the supplementary materials associated with the publication.

LABEL:

CoV_A549_up

SCORE TYPE:

P-Value

DATE ADDED:

2020-08-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Daniel Blanco-Melo, Benjamin E Nilsson-Payant, Wen-Chun Liu, Skyler Uhl, Daisy Hoagland, Rasmus Møller, Tristan X Jordan, Kohei Oishi, Maryline Panis, David Sachs, Taia T Wang, Robert E Schwartz, Jean K Lim, Randy A Albrecht, Benjamin R tenOever

TITLE:

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.

JOURNAL:

Cell 05 2020, Vol 181, pp. 1036-1045.e9

ABSTRACT:

Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. Cell and animal models of SARS-CoV-2 infection, in addition to transcriptional and serum profiling of COVID-19 patients, consistently revealed a unique and inappropriate inflammatory response. This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. We propose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19. PUBMED: 32416070
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