GeneSet Information

Tier I GS374486 • GO:1990565 HSP90-CDC37 chaperone complex

DESCRIPTION:

Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "HSP90-CDC37 chaperone complex", which is defined as "A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signalling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.12.

LABEL:

GO:1990565

SCORE TYPE:

Binary

DATE ADDED:

2020-04-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock

TITLE:

Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.

JOURNAL:

Nature genetics May 2000, Vol 25, pp. 25-9

Annotation Information

No sequence read archive data associated with this GeneSet.


No annotations are associated with this GeneSet.

Gene List • 2 Genes

Uploaded As Gene Symbol Homology Score Priority LinkOuts Emphasis