GeneSet Information

Tier II GS36134 • Neocortex Gene expression correlates of Activity during 1st tone shock pairing in Males BXD


Neocortex Gene Expression Correlates for LM_PAIR1 measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The LM_PAIR1 measures Activity during 1st tone shock pairing under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.











Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ


High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains.


Genes, brain, and behavior Mar 2010, Vol 9, pp. 129-59


Genetic reference populations, particularly the BXD recombinant inbred (BXD RI) strains derived from C57BL/6J and DBA/2J mice, are a valuable resource for the discovery of the bio-molecular substrates and genetic drivers responsible for trait variation and covariation. This approach can be profitably applied in the analysis of susceptibility and mechanisms of drug and alcohol use disorders for which many predisposing behaviors may predict the occurrence and manifestation of increased preference for these substances. Many of these traits are modeled by common mouse behavioral assays, facilitating the detection of patterns and sources of genetic coregulation of predisposing phenotypes and substance consumption. Members of the Tennessee Mouse Genome Consortium (TMGC) have obtained phenotype data from over 250 measures related to multiple behavioral assays across several batteries: response to, and withdrawal from cocaine, 3,4-methylenedioxymethamphetamine; \"ecstasy\" (MDMA), morphine and alcohol; novelty seeking; behavioral despair and related neurological phenomena; pain sensitivity; stress sensitivity; anxiety; hyperactivity and sleep/wake cycles. All traits have been measured in both sexes in approximately 70 strains of the recently expanded panel of BXD RI strains. Sex differences and heritability estimates were obtained for each trait, and a comparison of early (N = 32) and recent (N = 37) BXD RI lines was performed. Primary data are publicly available for heritability, sex difference and genetic analyses using the MouseTrack database, and are also available in for quantitative trait locus (QTL) detection and genetic analysis of gene expression. Together with the results of related studies, these data form a public resource for integrative systems genetic analysis of neurobehavioral traits. PUBMED: 19958391
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Annotation Information

Animals (D000818)
Organ Size (D009929)
Behavior (D001519)
Substance-Related Disorders (D019966)
Handling (Psychology) (D006234)
Behavior, Animal (D001522)
Quantitative Trait Loci (D040641)
Alcohol Drinking (D000428)
Recombination, Genetic (D011995)
RNA, Messenger (D012333)
Sex Characteristics (D012727)
Phenotype (D010641)
Cocaine-Related Disorders (D019970)
Cocaine (D003042)
Mice, Inbred C57BL (D008810)
Mice, Inbred DBA (D008811)
Tennessee (D013714)
Habituation, Psychophysiologic (D006185)
Neocortex (D019579)
Morphine Dependence (D009021)
Morphine (D009020)
Body Weight (D001835)
Housing, Animal (D006799)
Anxiety (D001007)
neocortex (MA:0002754)
behavioral despair (MP:0002573)
hyperactivity (MP:0001399)
gene expression (GO:0010467)

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