DESCRIPTION:

After chronic alcohol administration in male (control, n=6; alcohol, n=6) Sprague‐Dawley rats for 6 weeks, we analysed up‐ or downregulated genes using RNA sequencing technology. Genes up- or downregulated more than 1.5-fold in the alcohol-treated group compared to the control group

LABEL:

Rat hippocampus chronic alcohol

SCORE TYPE:

P-Value

DATE ADDED:

2019-10-22

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Mi Ran Choi, Jasmin Sanghyun Han, Young Gyu Chai, Yeung-Bae Jin, Sang-Rae Lee, Dai-Jin Kim

TITLE:

Gene expression profiling in the hippocampus of adolescent rats after chronic alcohol administration.

JOURNAL:

Basic & clinical pharmacology & toxicology Oct 2019, Vol None, pp. None

ABSTRACT:

In South Korea, the average age of onset of alcohol drinking is 13.3 years old and half of adolescents drink alcohol more than once a month; 8.45% of the Korean adolescent population become future high-risk alcohol drinkers. Chronic alcohol abuse causes physical and psychiatric health problems such as alcohol addiction, liver disease, stroke and cognitive impairments. This study aimed to investigate the effect of alcohol on gene expression and their function in the hippocampus of adolescent rats. After chronic alcohol administration in male (control, n=6; alcohol, n=6) Sprague-Dawley rats for 6 weeks, we analysed up- or downregulated genes using RNA sequencing technology. We found 83 genes more than 1.5-fold up- or downregulated in the alcohol-treated group. Among them, genes (Dnai1, Cfap206 and Dnah1) associated with cilium movement were upregulated in the alcohol-treated group. Mlf1, related to cell cycle arrest, was also upregulated in the alcohol-treated group. On the other hand, genes (Smad3 and Plk5) involved in negative regulation of cell proliferation were downregulated in the hippocampus by chronic alcohol administration. In addition, expression levels of genes associated with oxidative stress (Krt8 and Car3) and migration (Vim) were changed by chronic alcohol administration. These results pave a path for a better understanding of the neuromolecular mechanisms mediated by chronic alcohol exposure in the hippocampus of adolescents and negative pathology due to chronic alcohol abuse. PUBMED: 31628824
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