DESCRIPTION:

This set describes genes that are up-regulated in idiopathic epilepsy versus healthy patients. Expression analysis was performed by microarray analysis and adjusted p-values are <0.1. Values represent fold-change. Reported genes were mapped to HGNC identifers and only genes that could be mapped were included in the set.

LABEL:

up in idiopathic epilepsy versus healthy expression in blood

SCORE TYPE:

Effect

DATE ADDED:

2019-07-23

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Chitra Rawat, Suman Kushwaha, Achal K Srivastava, Ritushree Kukreti

TITLE:

Peripheral blood gene expression signatures associated with epilepsy and its etiologic classification.

JOURNAL:

Genomics Mar 2019, Vol None, pp. None

ABSTRACT:

Heterogeneity in epilepsy often interferes with its diagnosis as well as treatment. To examine this heterogeneity at transcriptomic level, we performed whole-genome mRNA expression profiling in whole blood samples from 34 patients with epilepsy (PWE) (idiopathic, n = 13; cryptogenic, n = 9; and symptomatic, n = 12) and 41 healthy controls (HC) using Illumina HT-12 Expression Beadchip v4 microarray. In silico analysis using R software identified 165 genes to be significantly differentially expressed in PWE compared to HC (fold change>1.3, p < 0.05). Hierarchical clustering of resultant DEGs segregated idiopathic epilepsy from the rest of the epilepsy classes as well as HC. The class also displayed the most differential expression pattern with the highest number of DEGs among the three epilepsy classes. Gene ontology analysis revealed several biologically relevant inflammatory and other immune-related pathways. Our study provides insight into the relevance of altered blood gene expression patterns in understanding epilepsy and its etiologic classes. PUBMED: 30826443
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