DESCRIPTION:

FBXW7 protein expression was very low in tumors with FBXW7 mutation led to loss of the protein (Fig. 2c). In an additional cohort (n = 40), we determined that FBXW7 protein was down-regulated in 33% tumors (Supplementary Fig.7; Supplementary Table 8b).

LABEL:

Protein down in ESCC

SCORE TYPE:

Correlation

DATE ADDED:

2018-04-16

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

De-Chen Lin, Jia-Jie Hao, Yasunobu Nagata, Liang Xu, Li Shang, Xuan Meng, Yusuke Sato, Yusuke Okuno, Ana Maria Varela, Ling-Wen Ding, Manoj Garg, Li-Zhen Liu, Henry Yang, Dong Yin, Zhi-Zhou Shi, Yan-Yi Jiang, Wen-Yue Gu, Ting Gong, Yu Zhang, Xin Xu, Ori Kalid, Sharon Shacham, Seishi Ogawa, Ming-Rong Wang, H Phillip Koeffler

TITLE:

Genomic and molecular characterization of esophageal squamous cell carcinoma.

JOURNAL:

Nature genetics May 2014, Vol 46, pp. 467-73

ABSTRACT:

Esophageal squamous cell carcinoma (ESCC) is prevalent worldwide and particularly common in certain regions of Asia. Here we report the whole-exome or targeted deep sequencing of 139 paired ESCC cases, and analysis of somatic copy number variations (SCNV) of over 180 ESCCs. We identified previously uncharacterized mutated genes such as FAT1, FAT2, ZNF750 and KMT2D, in addition to those already known (TP53, PIK3CA and NOTCH1). Further SCNV evaluation, immunohistochemistry and biological analysis suggested their functional relevance in ESCC. Notably, RTK-MAPK-PI3K pathways, cell cycle and epigenetic regulation are frequently dysregulated by multiple molecular mechanisms in this cancer. Our approaches also uncovered many druggable candidates, and XPO1 was further explored as a therapeutic target because it showed both gene mutation and protein overexpression. Our integrated study unmasks a number of novel genetic lesions in ESCC and provides an important molecular foundation for understanding esophageal tumors and developing therapeutic targets. PUBMED: 24686850
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