DESCRIPTION:

This gene set described genes that are up-regulated by the androgen receptor (AR). The set was derived by finding the intersection of a set of genes close to AR binding sites and a set of genes that were reported as AR-dependent. The set was further refined by microarray analysis of control and cells treated with synthetic androgen. The data is reported in supplementary file 1B and the HGNC gene symbols were used. The genes represent genes that were up-regulated at least 2-fold and the values represent the reported p-values.

LABEL:

Upregulated by AR in LNCaP

SCORE TYPE:

P-Value

DATE ADDED:

2018-04-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Liu S, Kumari S, Hu Q, Senapati D, Venkadakrishnan VB, Wang D, DePriest AD, Schlanger SE, Ben-Salem S, Valenzuela MM, Willard B, Mudambi S, Swetzig WM, Das GM, Shourideh M, Koochekpour S, Falzarano SM, Magi-Galluzzi C, Yadav N, Chen X, Lao C, Wang J, Billaud JN, Heemers HV

TITLE:

A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer.

JOURNAL:

eLife Aug 2017, Vol 6, pp. None

ABSTRACT:

Standard treatment for metastatic prostate cancer (CaP) prevents ligand-activation of androgen receptor (AR). Despite initial remission, CaP progresses while relying on AR. AR transcriptional output controls CaP behavior and is an alternative therapeutic target, but its molecular regulation is poorly understood. Here, we show that action of activated AR partitions into fractions that are controlled preferentially by different coregulators. In a 452-AR-target gene panel, each of 18 clinically relevant coregulators mediates androgen-responsiveness of 0-57% genes and acts as a coactivator or corepressor in a gene-specific manner. Selectivity in coregulator-dependent AR action is reflected in differential AR binding site composition and involvement with CaP biology and progression. Isolation of a novel transcriptional mechanism in which WDR77 unites the actions of AR and p53, the major genomic drivers of lethal CaP, to control cell cycle progression provides proof-of-principle for treatment via selective interference with AR action by exploiting AR dependence on coregulators. PUBMED: 28826481
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