DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Diffuse large B cell lymphoma. The EFO term diffuse large B-cell lymphoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: diffuse large B-cell lymphoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JR Cerhan, SI Berndt, J Vijai, H Ghesquières, J McKay, SS Wang, Z Wang, M Yeager, L Conde, PI de Bakker, A Nieters, D Cox, L Burdett, A Monnereau, CR Flowers, AJ De Roos, AR Brooks-Wilson, Q Lan, G Severi, M Melbye, J Gu, RD Jackson, E Kane, LR Teras, MP Purdue, CM Vajdic, JJ Spinelli, GG Giles, D Albanes, RS Kelly, M Zucca, KA Bertrand, A Zeleniuch-Jacquotte, C Lawrence, A Hutchinson, D Zhi, TM Habermann, BK Link, AJ Novak, A Dogan, YW Asmann, M Liebow, CA Thompson, SM Ansell, TE Witzig, GJ Weiner, AS Veron, D Zelenika, H Tilly, C Haioun, TJ Molina, H Hjalgrim, B Glimelius, HO Adami, PM Bracci, J Riby, MT Smith, EA Holly, W Cozen, P Hartge, LM Morton, RK Severson, LF Tinker, KE North, N Becker, Y Benavente, P Boffetta, P Brennan, L Foretova, M Maynadie, A Staines, T Lightfoot, S Crouch, A Smith, E Roman, WR Diver, K Offit, A Zelenetz, RJ Klein, DJ Villano, T Zheng, Y Zhang, TR Holford, A Kricker, J Turner, MC Southey, J Clavel, J Virtamo, S Weinstein, E Riboli, P Vineis, R Kaaks, D Trichopoulos, RC Vermeulen, H Boeing, A Tjonneland, E Angelucci, S Di Lollo, M Rais, BM Birmann, F Laden, E Giovannucci, P Kraft, J Huang, B Ma, Y Ye, BC Chiu, J Sampson, L Liang, JH Park, CC Chung, DD Weisenburger, N Chatterjee, JF Fraumeni, SL Slager, X Wu, S de Sanjose, KE Smedby, G Salles, CF Skibola, N Rothman, SJ Chanock

TITLE:

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.

JOURNAL:

Nature genetics Nov 2014, Vol 46, pp. 1233-8

ABSTRACT:

Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10(-13) and 3.63 × 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL. PUBMED: 25261932
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