DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Atopic dermatitis. The EFO term atopic eczema was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: atopic eczema

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

LD Sun, FL Xiao, Y Li, WM Zhou, HY Tang, XF Tang, H Zhang, H Schaarschmidt, XB Zuo, R Foelster-Holst, SM He, M Shi, Q Liu, YM Lv, XL Chen, KJ Zhu, YF Guo, DY Hu, M Li, M Li, YH Zhang, X Zhang, JP Tang, BR Guo, H Wang, Y Liu, XY Zou, FS Zhou, XY Liu, G Chen, L Ma, SM Zhang, AP Jiang, XD Zheng, XH Gao, P Li, CX Tu, XY Yin, XP Han, YQ Ren, SP Song, ZY Lu, XL Zhang, Y Cui, J Chang, M Gao, XY Luo, PG Wang, X Dai, W Su, H Li, CP Shen, SX Liu, XB Feng, CJ Yang, GS Lin, ZX Wang, JQ Huang, X Fan, Y Wang, YX Bao, S Yang, JJ Liu, A Franke, S Weidinger, ZR Yao, XJ Zhang

TITLE:

Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population.

JOURNAL:

Nature genetics Jun 2011, Vol 43, pp. 690-4

ABSTRACT:

Atopic dermatitis is a chronic, relapsing form of inflammatory skin disorder that is affected by genetic and environmental factors. We performed a genome-wide association study of atopic dermatitis in a Chinese Han population using 1,012 affected individuals (cases) and 1,362 controls followed by a replication study in an additional 3,624 cases and 12,197 controls of Chinese Han ethnicity, as well as 1,806 cases and 3,256 controls from Germany. We identified previously undescribed susceptibility loci at 5q22.1 (TMEM232 and SLC25A46, rs7701890, P(combined) = 3.15 × 10(-9), odds ratio (OR) = 1.24) and 20q13.33 (TNFRSF6B and ZGPAT, rs6010620, P(combined) = 3.0 × 10(-8), OR = 1.17) and replicated another previously reported locus at 1q21.3 (FLG, rs3126085, P(combined) = 5.90 × 10(-12), OR = 0.82) in the Chinese sample. The 20q13.33 locus also showed evidence for association in the German sample (rs6010620, P = 2.87 × 10(-5), OR = 1.25). Our study identifies new genetic susceptibility factors and suggests previously unidentified biological pathways in atopic dermatitis. PUBMED: 21666691
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