DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Attention deficit hyperactivity disorder. The EFO term attention deficit hyperactivity disorder was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: attention deficit hyperactivity disorder

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

KP Lesch, N Timmesfeld, TJ Renner, R Halperin, C Röser, TT Nguyen, DW Craig, J Romanos, M Heine, J Meyer, C Freitag, A Warnke, M Romanos, H Schäfer, S Walitza, A Reif, DA Stephan, C Jacob

TITLE:

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.

JOURNAL:

Journal of neural transmission (Vienna, Austria : 1996) Nov 2008, Vol 115, pp. 1573-85

ABSTRACT:

A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing approximately 500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability. PUBMED: 18839057
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