DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Breast cancer. The EFO term breast carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: breast carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M Garcia-Closas, FJ Couch, S Lindstrom, K Michailidou, MK Schmidt, MN Brook, N Orr, SK Rhie, E Riboli, HS Feigelson, L Le Marchand, JE Buring, D Eccles, P Miron, PA Fasching, H Brauch, J Chang-Claude, J Carpenter, AK Godwin, H Nevanlinna, GG Giles, A Cox, JL Hopper, MK Bolla, Q Wang, J Dennis, E Dicks, WJ Howat, N Schoof, SE Bojesen, D Lambrechts, A Broeks, IL Andrulis, P Guénel, B Burwinkel, EJ Sawyer, A Hollestelle, O Fletcher, R Winqvist, H Brenner, A Mannermaa, U Hamann, A Meindl, A Lindblom, W Zheng, P Devillee, MS Goldberg, J Lubinski, V Kristensen, A Swerdlow, H Anton-Culver, T Dörk, K Muir, K Matsuo, AH Wu, P Radice, SH Teo, XO Shu, W Blot, D Kang, M Hartman, S Sangrajrang, CY Shen, MC Southey, DJ Park, F Hammet, J Stone, LJ Veer, EJ Rutgers, A Lophatananon, S Stewart-Brown, P Siriwanarangsan, J Peto, MG Schrauder, AB Ekici, MW Beckmann, I Dos Santos Silva, N Johnson, H Warren, I Tomlinson, MJ Kerin, N Miller, F Marme, A Schneeweiss, C Sohn, T Truong, P Laurent-Puig, P Kerbrat, BG Nordestgaard, SF Nielsen, H Flyger, RL Milne, JI Perez, P Menéndez, H Müller, V Arndt, C Stegmaier, P Lichtner, M Lochmann, C Justenhoven, YD Ko, TA Muranen, K Aittomäki, C Blomqvist, D Greco, T Heikkinen, H Ito, H Iwata, Y Yatabe, NN Antonenkova, S Margolin, V Kataja, VM Kosma, JM Hartikainen, R Balleine, CC Tseng, DV Berg, DO Stram, P Neven, AS Dieudonné, K Leunen, A Rudolph, S Nickels, D Flesch-Janys, P Peterlongo, B Peissel, L Bernard, JE Olson, X Wang, K Stevens, G Severi, L Baglietto, C McLean, GA Coetzee, Y Feng, BE Henderson, F Schumacher, NV Bogdanova, F Labrèche, M Dumont, CH Yip, NA Taib, CY Cheng, M Shrubsole, J Long, K Pylkäs, A Jukkola-Vuorinen, S Kauppila, JA Knight, G Glendon, AM Mulligan, RA Tollenaar, CM Seynaeve, M Kriege, MJ Hooning, AM van den Ouweland, CH van Deurzen, W Lu, YT Gao, H Cai, SP Balasubramanian, SS Cross, MW Reed, L Signorello, Q Cai, M Shah, H Miao, CW Chan, KS Chia, A Jakubowska, K Jaworska, K Durda, CN Hsiung, PE Wu, JC Yu, A Ashworth, M Jones, DC Tessier, A González-Neira, G Pita, MR Alonso, D Vincent, F Bacot, CB Ambrosone, EV Bandera, EM John, GK Chen, JJ Hu, JL Rodriguez-Gil, L Bernstein, MF Press, RG Ziegler, RM Millikan, SL Deming-Halverson, S Nyante, SA Ingles, Q Waisfisz, H Tsimiklis, E Makalic, D Schmidt, M Bui, L Gibson, B Müller-Myhsok, RK Schmutzler, R Hein, N Dahmen, L Beckmann, K Aaltonen, K Czene, A Irwanto, J Liu, C Turnbull, N Rahman, H Meijers-Heijboer, AG Uitterlinden, F Rivadeneira, C Olswold, S Slager, R Pilarski, F Ademuyiwa, I Konstantopoulou, NG Martin, GW Montgomery, DJ Slamon, C Rauh, MP Lux, SM Jud, T Bruning, J Weaver, P Sharma, H Pathak, W Tapper, S Gerty, L Durcan, D Trichopoulos, R Tumino, PH Peeters, R Kaaks, D Campa, F Canzian, E Weiderpass, M Johansson, KT Khaw, R Travis, F Clavel-Chapelon, LN Kolonel, C Chen, A Beck, SE Hankinson, CD Berg, RN Hoover, J Lissowska, JD Figueroa, DI Chasman, MM Gaudet, WR Diver, WC Willett, DJ Hunter, J Simard, J Benitez, AM Dunning, ME Sherman, G Chenevix-Trench, SJ Chanock, P Hall, PD Pharoah, C Vachon, DF Easton, CA Haiman, P Kraft

TITLE:

Genome-wide association studies identify four ER negative-specific breast cancer risk loci.

JOURNAL:

Nature genetics Apr 2013, Vol 45, pp. 392-8, 398e1-2

ABSTRACT:

Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10(-12) and LGR6, P = 1.4 × 10(-8)), 2p24.1 (P = 4.6 × 10(-8)) and 16q12.2 (FTO, P = 4.0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers. PUBMED: 23535733
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