DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Creatinine levels. The EFO term serum creatinine measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: serum creatinine measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JC Chambers, W Zhang, GM Lord, P van der Harst, DA Lawlor, JS Sehmi, DP Gale, MN Wass, KR Ahmadi, SJ Bakker, J Beckmann, HJ Bilo, M Bochud, MJ Brown, MJ Caulfield, JM Connell, HT Cook, I Cotlarciuc, G Davey Smith, R de Silva, G Deng, O Devuyst, LD Dikkeschei, N Dimkovic, M Dockrell, A Dominiczak, S Ebrahim, T Eggermann, M Farrall, L Ferrucci, J Floege, NG Forouhi, RT Gansevoort, X Han, B Hedblad, JJ Homan van der Heide, BG Hepkema, M Hernandez-Fuentes, E Hypponen, T Johnson, PE de Jong, N Kleefstra, V Lagou, M Lapsley, Y Li, RJ Loos, J Luan, K Luttropp, C Maréchal, O Melander, PB Munroe, L Nordfors, A Parsa, L Peltonen, BW Penninx, E Perucha, A Pouta, I Prokopenko, PJ Roderick, A Ruokonen, NJ Samani, S Sanna, M Schalling, D Schlessinger, G Schlieper, MA Seelen, AR Shuldiner, M Sjögren, JH Smit, H Snieder, N Soranzo, TD Spector, P Stenvinkel, MJ Sternberg, R Swaminathan, T Tanaka, LJ Ubink-Veltmaat, M Uda, P Vollenweider, C Wallace, D Waterworth, K Zerres, G Waeber, NJ Wareham, PH Maxwell, MI McCarthy, MR Jarvelin, V Mooser, GR Abecasis, L Lightstone, J Scott, G Navis, P Elliott, JS Kooner

TITLE:

Genetic loci influencing kidney function and chronic kidney disease.

JOURNAL:

Nature genetics May 2010, Vol 42, pp. 373-5

ABSTRACT:

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease. PUBMED: 20383145
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