DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Chronic kidney disease. The EFO term chronic kidney disease, serum creatinine measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: chronic kidney disease, serum creatinine measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

A Köttgen, C Pattaro, CA Böger, C Fuchsberger, M Olden, NL Glazer, A Parsa, X Gao, Q Yang, AV Smith, JR O'Connell, M Li, H Schmidt, T Tanaka, A Isaacs, S Ketkar, SJ Hwang, AD Johnson, A Dehghan, A Teumer, G Paré, EJ Atkinson, T Zeller, K Lohman, MC Cornelis, NM Probst-Hensch, F Kronenberg, A Tönjes, C Hayward, T Aspelund, G Eiriksdottir, LJ Launer, TB Harris, E Rampersaud, BD Mitchell, DE Arking, E Boerwinkle, M Struchalin, M Cavalieri, A Singleton, F Giallauria, J Metter, IH de Boer, T Haritunians, T Lumley, D Siscovick, BM Psaty, MC Zillikens, BA Oostra, M Feitosa, M Province, M de Andrade, ST Turner, A Schillert, A Ziegler, PS Wild, RB Schnabel, S Wilde, TF Munzel, TS Leak, T Illig, N Klopp, C Meisinger, HE Wichmann, W Koenig, L Zgaga, T Zemunik, I Kolcic, C Minelli, FB Hu, A Johansson, W Igl, G Zaboli, SH Wild, AF Wright, H Campbell, D Ellinghaus, S Schreiber, YS Aulchenko, JF Felix, F Rivadeneira, AG Uitterlinden, A Hofman, M Imboden, D Nitsch, A Brandstätter, B Kollerits, L Kedenko, R Mägi, M Stumvoll, P Kovacs, M Boban, S Campbell, K Endlich, H Völzke, HK Kroemer, M Nauck, U Völker, O Polasek, V Vitart, S Badola, AN Parker, PM Ridker, SL Kardia, S Blankenberg, Y Liu, GC Curhan, A Franke, T Rochat, B Paulweber, I Prokopenko, W Wang, V Gudnason, AR Shuldiner, J Coresh, R Schmidt, L Ferrucci, MG Shlipak, CM van Duijn, I Borecki, BK Krämer, I Rudan, U Gyllensten, JF Wilson, JC Witteman, PP Pramstaller, R Rettig, N Hastie, DI Chasman, WH Kao, IM Heid, CS Fox

TITLE:

New loci associated with kidney function and chronic kidney disease.

JOURNAL:

Nature genetics May 2010, Vol 42, pp. 376-84

ABSTRACT:

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney. PUBMED: 20383146
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