DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Paclitaxel-induced neuropathy. The EFO term brain serotonin transporter measurement, response to paclitaxel was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: brain serotonin transporter measurement, response to paclitaxel

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

LJ Leandro-García, L Inglada-Pérez, G Pita, E Hjerpe, S Leskelä, C Jara, X Mielgo, A González-Neira, M Robledo, E Avall-Lundqvist, H Gréen, C Rodríguez-Antona

TITLE:

Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.

JOURNAL:

Journal of medical genetics Sep 2013, Vol 50, pp. 599-605

ABSTRACT:

Peripheral neuropathy is the dose limiting toxicity of paclitaxel, a chemotherapeutic drug widely used to treat solid tumours. This toxicity exhibits great inter-individual variability of unknown origin. The present study aimed to identify genetic variants associated with paclitaxel induced neuropathy via a whole genome approach. PUBMED: 23776197
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