DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Adolescent idiopathic scoliosis. The EFO term adolescent idiopathic scoliosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: adolescent idiopathic scoliosis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Z Zhu, NL Tang, L Xu, X Qin, S Mao, Y Song, L Liu, F Li, P Liu, L Yi, J Chang, L Jiang, BK Ng, B Shi, W Zhang, J Qiao, X Sun, X Qiu, Z Wang, F Wang, D Xie, L Chen, Z Chen, M Jin, X Han, Z Hu, Z Zhang, Z Liu, F Zhu, BP Qian, Y Yu, B Wang, KM Lee, WY Lee, TP Lam, Y Qiu, JC Cheng

TITLE:

Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls.

JOURNAL:

Nature communications Sep 2015, Vol 6, pp. 8355

ABSTRACT:

Adolescent idiopathic scoliosis (AIS) is a structural deformity of the spine affecting millions of children. As a complex disease, the genetic aetiology of AIS remains obscure. Here we report the results of a four-stage genome-wide association study (GWAS) conducted in a sample of 4,317 AIS patients and 6,016 controls. Overall, we identify three new susceptibility loci at 1p36.32 near AJAP1 (rs241215, Pcombined=2.95 × 10(-9)), 2q36.1 between PAX3 and EPHA4 (rs13398147, Pcombined=7.59 × 10(-13)) and 18q21.33 near BCL-2 (rs4940576, Pcombined=2.22 × 10(-12)). In addition, we refine a previously reported region associated with AIS at 10q24.32 (rs678741, Pcombined=9.68 × 10(-37)), which suggests LBX1AS1, encoding an antisense transcript of LBX1, might be a functional variant of AIS. This is the first GWAS investigating genetic variants associated with AIS in Chinese population, and the findings provide new insight into the multiple aetiological mechanisms of AIS. PUBMED: 26394188
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