DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Systolic blood pressure. The EFO term systolic blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: systolic blood pressure

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

X Lu, L Wang, X Lin, J Huang, C Charles Gu, M He, H Shen, J He, J Zhu, H Li, JE Hixson, T Wu, J Dai, L Lu, C Shen, S Chen, L He, Z Mo, Y Hao, X Mo, X Yang, J Li, J Cao, J Chen, Z Fan, Y Li, L Zhao, H Li, F Lu, C Yao, L Yu, L Xu, J Mu, X Wu, Y Deng, D Hu, W Zhang, X Ji, D Guo, Z Guo, Z Zhou, Z Yang, R Wang, J Yang, X Zhou, W Yan, N Sun, P Gao, D Gu

TITLE:

Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.

JOURNAL:

Human molecular genetics Feb 2015, Vol 24, pp. 865-74

ABSTRACT:

Hypertension is a common disorder and the leading risk factor for cardiovascular disease and premature deaths worldwide. Genome-wide association studies (GWASs) in the European population have identified multiple chromosomal regions associated with blood pressure, and the identified loci altogether explain only a small fraction of the variance for blood pressure. The differences in environmental exposures and genetic background between Chinese and European populations might suggest potential different pathways of blood pressure regulation. To identify novel genetic variants affecting blood pressure variation, we conducted a meta-analysis of GWASs of blood pressure and hypertension in 11 816 subjects followed by replication studies including 69 146 additional individuals. We identified genome-wide significant (P < 5.0 × 10(-8)) associations with blood pressure, which included variants at three new loci (CACNA1D, CYP21A2, and MED13L) and a newly discovered variant near SLC4A7. We also replicated 14 previously reported loci, 8 (CASZ1, MOV10, FGF5, CYP17A1, SOX6, ATP2B1, ALDH2, and JAG1) at genome-wide significance, and 6 (FIGN, ULK4, GUCY1A3, HFE, TBX3-TBX5, and TBX3) at a suggestive level of P = 1.81 × 10(-3) to 5.16 × 10(-8). These findings provide new mechanistic insights into the regulation of blood pressure and potential targets for treatments. PUBMED: 25249183
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