DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Systemic lupus erythematosus. The EFO term systemic lupus erythematosus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: systemic lupus erythematosus

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

G Hom, RR Graham, B Modrek, KE Taylor, W Ortmann, S Garnier, AT Lee, SA Chung, RC Ferreira, PV Pant, DG Ballinger, R Kosoy, FY Demirci, MI Kamboh, AH Kao, C Tian, I Gunnarsson, AA Bengtsson, S Rantapää-Dahlqvist, M Petri, S Manzi, MF Seldin, L Rönnblom, AC Syvänen, LA Criswell, PK Gregersen, TW Behrens

TITLE:

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

JOURNAL:

The New England journal of medicine Feb 2008, Vol 358, pp. 900-9

ABSTRACT:

Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions. Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci. PUBMED: 18204098
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