DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Multiple myeloma (survival). The EFO term overall survival, multiple myeloma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: overall survival, multiple myeloma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

E Ziv, E Dean, D Hu, A Martino, D Serie, K Curtin, D Campa, B Aftab, P Bracci, G Buda, Y Zhao, J Caswell-Jin, R Diasio, C Dumontet, M Dudziński, L Fejerman, A Greenberg, S Huntsman, K Jamroziak, A Jurczyszyn, S Kumar, D Atanackovic, M Glenn, LA Cannon-Albright, B Jones, A Lee, H Marques, T Martin, J Martinez-Lopez, V Rajkumar, J Sainz, AJ Vangsted, M Wątek, J Wolf, S Slager, NJ Camp, F Canzian, C Vachon

TITLE:

Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients.

JOURNAL:

Nature communications Jul 2015, Vol 6, pp. 7539

ABSTRACT:

Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1.94-3.58) relative to patients homozygous for the major allele. We replicate the association in the IMMEnSE cohort including 772 patients, and a University of Utah cohort including 318 patients (rs72773978 P=0.044). Using publicly available data, we find that the minor allele was associated with increased expression of FOPNL and increased expression of FOPNL was associated with higher expression of centrosomal genes and with shorter survival. Polymorphisms at the FOPNL locus are associated with survival among MM patients. PUBMED: 26198393
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