DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Glioma. The EFO term central nervous system cancer was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: central nervous system cancer

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

S Shete, FJ Hosking, LB Robertson, SE Dobbins, M Sanson, B Malmer, M Simon, Y Marie, B Boisselier, JY Delattre, K Hoang-Xuan, S El Hallani, A Idbaih, D Zelenika, U Andersson, R Henriksson, AT Bergenheim, M Feychting, S Lönn, A Ahlbom, J Schramm, M Linnebank, K Hemminki, R Kumar, SJ Hepworth, A Price, G Armstrong, Y Liu, X Gu, R Yu, C Lau, M Schoemaker, K Muir, A Swerdlow, M Lathrop, M Bondy, RS Houlston

TITLE:

Genome-wide association study identifies five susceptibility loci for glioma.

JOURNAL:

Nature genetics Aug 2009, Vol 41, pp. 899-904

ABSTRACT:

To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor. PUBMED: 19578367
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