DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Sleep duration. The EFO term sleep duration was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: sleep duration

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DJ Gottlieb, K Hek, TH Chen, NF Watson, G Eiriksdottir, EM Byrne, M Cornelis, SC Warby, S Bandinelli, L Cherkas, DS Evans, HJ Grabe, J Lahti, M Li, T Lehtimäki, T Lumley, KD Marciante, L Pérusse, BM Psaty, J Robbins, GJ Tranah, JM Vink, JB Wilk, JM Stafford, C Bellis, R Biffar, C Bouchard, B Cade, GC Curhan, JG Eriksson, R Ewert, L Ferrucci, T Fülöp, PR Gehrman, R Goodloe, TB Harris, AC Heath, D Hernandez, A Hofman, JJ Hottenga, DJ Hunter, MK Jensen, AD Johnson, M Kähönen, L Kao, P Kraft, EK Larkin, DS Lauderdale, AI Luik, M Medici, GW Montgomery, A Palotie, SR Patel, G Pistis, E Porcu, L Quaye, O Raitakari, S Redline, EB Rimm, JI Rotter, AV Smith, TD Spector, A Teumer, AG Uitterlinden, MC Vohl, E Widen, G Willemsen, T Young, X Zhang, Y Liu, J Blangero, DI Boomsma, V Gudnason, F Hu, M Mangino, NG Martin, GT O'Connor, KL Stone, T Tanaka, J Viikari, SA Gharib, NM Punjabi, K Räikkönen, H Völzke, E Mignot, H Tiemeier

TITLE:

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.

JOURNAL:

Molecular psychiatry Oct 2015, Vol 20, pp. 1232-9

ABSTRACT:

Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10(-4)). The strongest combined association was at rs1823125 (P=1.5 × 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease. PUBMED: 25469926
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