DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Tourette's syndrome or obsessive-compulsive disorder. The EFO term obsessive-compulsive disorder, Tourette syndrome was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: obsessive-compulsive disorder, Tourette syndrome

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

D Yu, CA Mathews, JM Scharf, BM Neale, LK Davis, ER Gamazon, EM Derks, P Evans, CK Edlund, J Crane, JA Fagerness, L Osiecki, P Gallagher, G Gerber, S Haddad, C Illmann, LM McGrath, C Mayerfeld, S Arepalli, C Barlassina, CL Barr, L Bellodi, F Benarroch, GB Berrió, OJ Bienvenu, DW Black, MH Bloch, H Brentani, RD Bruun, CL Budman, B Camarena, DD Campbell, C Cappi, JC Silgado, MC Cavallini, DA Chavira, S Chouinard, EH Cook, MR Cookson, V Coric, B Cullen, D Cusi, R Delorme, D Denys, Y Dion, V Eapen, K Egberts, P Falkai, T Fernandez, E Fournier, H Garrido, D Geller, DL Gilbert, SL Girard, HJ Grabe, MA Grados, BD Greenberg, V Gross-Tsur, E Grünblatt, J Hardy, GA Heiman, SM Hemmings, LD Herrera, DM Hezel, PJ Hoekstra, J Jankovic, JL Kennedy, RA King, AI Konkashbaev, B Kremeyer, R Kurlan, N Lanzagorta, M Leboyer, JF Leckman, L Lennertz, C Liu, C Lochner, TL Lowe, S Lupoli, F Macciardi, W Maier, P Manunta, M Marconi, JT McCracken, SC Mesa Restrepo, R Moessner, P Moorjani, J Morgan, H Muller, DL Murphy, AL Naarden, E Nurmi, WC Ochoa, RA Ophoff, AJ Pakstis, MT Pato, CN Pato, J Piacentini, C Pittenger, Y Pollak, SL Rauch, T Renner, VI Reus, MA Richter, MA Riddle, MM Robertson, R Romero, MC Rosário, D Rosenberg, S Ruhrmann, C Sabatti, E Salvi, AS Sampaio, J Samuels, P Sandor, SK Service, B Sheppard, HS Singer, JH Smit, DJ Stein, E Strengman, JA Tischfield, M Turiel, AV Valencia Duarte, H Vallada, J Veenstra-VanderWeele, S Walitza, Y Wang, M Weale, R Weiss, JR Wendland, HG Westenberg, YY Shugart, AG Hounie, EC Miguel, H Nicolini, M Wagner, A Ruiz-Linares, DC Cath, W McMahon, D Posthuma, BA Oostra, G Nestadt, GA Rouleau, S Purcell, MA Jenike, P Heutink, GL Hanna, DV Conti, PD Arnold, NB Freimer, SE Stewart, JA Knowles, NJ Cox, DL Pauls

TITLE:

Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.

JOURNAL:

The American journal of psychiatry Jan 2015, Vol 172, pp. 82-93

ABSTRACT:

Obsessive-compulsive disorder (OCD) and Tourette's syndrome are highly heritable neurodevelopmental disorders that are thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologically complex disorders remains elusive. The authors report a combined genome-wide association study (GWAS) of Tourette's syndrome and OCD. PUBMED: 25158072
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