DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Hodgkin's lymphoma. The EFO term Hodgkins lymphoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Hodgkins lymphoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M Frampton, MI da Silva Filho, P Broderick, H Thomsen, A Försti, J Vijayakrishnan, R Cooke, V Enciso-Mora, P Hoffmann, MM Nöthen, A Lloyd, A Holroyd, L Eisele, KH Jöckel, S Ponader, EP von Strandmann, T Lightfoot, E Roman, A Lake, D Montgomery, RF Jarrett, AJ Swerdlow, A Engert, K Hemminki, RS Houlston

TITLE:

Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.

JOURNAL:

Nature communications None 2013, Vol 4, pp. 2549

ABSTRACT:

In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10(-12), odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10(-9), OR=1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL. PUBMED: 24149102
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