DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Primary biliary cirrhosis. The EFO term biliary liver cirrhosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: biliary liver cirrhosis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

GM Hirschfield, X Liu, C Xu, Y Lu, G Xie, Y Lu, X Gu, EJ Walker, K Jing, BD Juran, AL Mason, RP Myers, KM Peltekian, CN Ghent, C Coltescu, EJ Atkinson, EJ Heathcote, KN Lazaridis, CI Amos, KA Siminovitch

TITLE:

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

JOURNAL:

The New England journal of medicine Jun 2009, Vol 360, pp. 2544-55

ABSTRACT:

Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown. PUBMED: 19458352
Find other GeneSets from this publication