DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Prostate cancer. The EFO term prostate carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: prostate carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

RA Eeles, Z Kote-Jarai, GG Giles, AA Olama, M Guy, SK Jugurnauth, S Mulholland, DA Leongamornlert, SM Edwards, J Morrison, HI Field, MC Southey, G Severi, JL Donovan, FC Hamdy, DP Dearnaley, KR Muir, C Smith, M Bagnato, AT Ardern-Jones, AL Hall, LT O'Brien, BN Gehr-Swain, RA Wilkinson, A Cox, S Lewis, PM Brown, SG Jhavar, M Tymrakiewicz, A Lophatananon, SL Bryant, A Horwich, RA Huddart, VS Khoo, CC Parker, CJ Woodhouse, A Thompson, T Christmas, C Ogden, C Fisher, C Jamieson, CS Cooper, DR English, JL Hopper, DE Neal, DF Easton

TITLE:

Multiple newly identified loci associated with prostate cancer susceptibility.

JOURNAL:

Nature genetics Mar 2008, Vol 40, pp. 316-21

ABSTRACT:

Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at </=60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform. Initial putative associations were confirmed using a further 3,268 cases and 3,366 controls. We identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X (P = 2.7 x 10(-8) to P = 8.7 x 10(-29)). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3. PUBMED: 18264097
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