GeneSet Information

Tier I GS270774 • GWAS Catalog Data for body mass index in up to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals

DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Body mass index. The EFO term body mass index was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body mass index

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

312

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

AE Locke, B Kahali, SI Berndt, AE Justice, TH Pers, FR Day, C Powell, S Vedantam, ML Buchkovich, J Yang, DC Croteau-Chonka, T Esko, T Fall, T Ferreira, S Gustafsson, Z Kutalik, J Luan, R Mägi, JC Randall, TW Winkler, AR Wood, T Workalemahu, JD Faul, JA Smith, J Hua Zhao, W Zhao, J Chen, R Fehrmann, ÅK Hedman, J Karjalainen, EM Schmidt, D Absher, N Amin, D Anderson, M Beekman, JL Bolton, JL Bragg-Gresham, S Buyske, A Demirkan, G Deng, GB Ehret, B Feenstra, MF Feitosa, K Fischer, A Goel, J Gong, AU Jackson, S Kanoni, ME Kleber, K Kristiansson, U Lim, V Lotay, M Mangino, I Mateo Leach, C Medina-Gomez, SE Medland, MA Nalls, CD Palmer, D Pasko, S Pechlivanis, MJ Peters, I Prokopenko, D Shungin, A Stančáková, RJ Strawbridge, Y Ju Sung, T Tanaka, A Teumer, S Trompet, SW van der Laan, J van Setten, JV Van Vliet-Ostaptchouk, Z Wang, L Yengo, W Zhang, A Isaacs, E Albrecht, J Ärnlöv, GM Arscott, AP Attwood, S Bandinelli, A Barrett, IN Bas, C Bellis, AJ Bennett, C Berne, R Blagieva, M Blüher, S Böhringer, LL Bonnycastle, Y Böttcher, HA Boyd, M Bruinenberg, IH Caspersen, YD Ida Chen, R Clarke, EW Daw, AJ de Craen, G Delgado, M Dimitriou, AS Doney, N Eklund, K Estrada, E Eury, L Folkersen, RM Fraser, ME Garcia, F Geller, V Giedraitis, B Gigante, AS Go, A Golay, AH Goodall, SD Gordon, M Gorski, HJ Grabe, H Grallert, TB Grammer, J Gräßler, H Grönberg, CJ Groves, G Gusto, J Haessler, P Hall, T Haller, G Hallmans, CA Hartman, M Hassinen, C Hayward, NL Heard-Costa, Q Helmer, C Hengstenberg, O Holmen, JJ Hottenga, AL James, JM Jeff, Å Johansson, J Jolley, T Juliusdottir, L Kinnunen, W Koenig, M Koskenvuo, W Kratzer, J Laitinen, C Lamina, K Leander, NR Lee, P Lichtner, L Lind, J Lindström, K Sin Lo, S Lobbens, R Lorbeer, Y Lu, F Mach, PK Magnusson, A Mahajan, WL McArdle, S McLachlan, C Menni, S Merger, E Mihailov, L Milani, A Moayyeri, KL Monda, MA Morken, A Mulas, G Müller, M Müller-Nurasyid, AW Musk, R Nagaraja, MM Nöthen, IM Nolte, S Pilz, NW Rayner, F Renstrom, R Rettig, JS Ried, S Ripke, NR Robertson, LM Rose, S Sanna, H Scharnagl, S Scholtens, FR Schumacher, WR Scott, T Seufferlein, J Shi, A Vernon Smith, J Smolonska, AV Stanton, V Steinthorsdottir, K Stirrups, HM Stringham, J Sundström, MA Swertz, AJ Swift, AC Syvänen, ST Tan, BO Tayo, B Thorand, G Thorleifsson, JP Tyrer, HW Uh, L Vandenput, FC Verhulst, SH Vermeulen, N Verweij, JM Vonk, LL Waite, HR Warren, D Waterworth, MN Weedon, LR Wilkens, C Willenborg, T Wilsgaard, MK Wojczynski, A Wong, AF Wright, Q Zhang, EP Brennan, M Choi, Z Dastani, AW Drong, P Eriksson, A Franco-Cereceda, JR Gådin, AG Gharavi, ME Goddard, RE Handsaker, J Huang, F Karpe, S Kathiresan, S Keildson, K Kiryluk, M Kubo, JY Lee, L Liang, RP Lifton, B Ma, SA McCarroll, AJ McKnight, JL Min, MF Moffatt, GW Montgomery, JM Murabito, G Nicholson, DR Nyholt, Y Okada, JR Perry, R Dorajoo, E Reinmaa, RM Salem, N Sandholm, RA Scott, L Stolk, A Takahashi, T Tanaka, FM Van't Hooft, AA Vinkhuyzen, HJ Westra, W Zheng, KT Zondervan, AC Heath, D Arveiler, SJ Bakker, J Beilby, RN Bergman, J Blangero, P Bovet, H Campbell, MJ Caulfield, G Cesana, A Chakravarti, DI Chasman, PS Chines, FS Collins, DC Crawford, LA Cupples, D Cusi, J Danesh, U de Faire, HM den Ruijter, AF Dominiczak, R Erbel, J Erdmann, JG Eriksson, M Farrall, SB Felix, E Ferrannini, J Ferrières, I Ford, NG Forouhi, T Forrester, OH Franco, RT Gansevoort, PV Gejman, C Gieger, O Gottesman, V Gudnason, U Gyllensten, AS Hall, TB Harris, AT Hattersley, AA Hicks, LA Hindorff, AD Hingorani, A Hofman, G Homuth, GK Hovingh, SE Humphries, SC Hunt, E Hyppönen, T Illig, KB Jacobs, MR Jarvelin, KH Jöckel, B Johansen, P Jousilahti, JW Jukema, AM Jula, J Kaprio, JJ Kastelein, SM Keinanen-Kiukaanniemi, LA Kiemeney, P Knekt, JS Kooner, C Kooperberg, P Kovacs, AT Kraja, M Kumari, J Kuusisto, TA Lakka, C Langenberg, L Le Marchand, T Lehtimäki, V Lyssenko, S Männistö, A Marette, TC Matise, CA McKenzie, B McKnight, FL Moll, AD Morris, AP Morris, JC Murray, M Nelis, C Ohlsson, AJ Oldehinkel, KK Ong, PA Madden, G Pasterkamp, JF Peden, A Peters, DS Postma, PP Pramstaller, JF Price, L Qi, OT Raitakari, T Rankinen, DC Rao, TK Rice, PM Ridker, JD Rioux, MD Ritchie, I Rudan, V Salomaa, NJ Samani, J Saramies, MA Sarzynski, H Schunkert, PE Schwarz, P Sever, AR Shuldiner, J Sinisalo, RP Stolk, K Strauch, A Tönjes, DA Trégouët, A Tremblay, E Tremoli, J Virtamo, MC Vohl, U Völker, G Waeber, G Willemsen, JC Witteman, MC Zillikens, LS Adair, P Amouyel, FW Asselbergs, TL Assimes, M Bochud, BO Boehm, E Boerwinkle, SR Bornstein, EP Bottinger, C Bouchard, S Cauchi, JC Chambers, SJ Chanock, RS Cooper, PI de Bakker, G Dedoussis, L Ferrucci, PW Franks, P Froguel, LC Groop, CA Haiman, A Hamsten, J Hui, DJ Hunter, K Hveem, RC Kaplan, M Kivimaki, D Kuh, M Laakso, Y Liu, NG Martin, W März, M Melbye, A Metspalu, S Moebus, PB Munroe, I Njølstad, BA Oostra, CN Palmer, NL Pedersen, M Perola, L Pérusse, U Peters, C Power, T Quertermous, R Rauramaa, F Rivadeneira, TE Saaristo, D Saleheen, N Sattar, EE Schadt, D Schlessinger, PE Slagboom, H Snieder, TD Spector, U Thorsteinsdottir, M Stumvoll, J Tuomilehto, AG Uitterlinden, M Uusitupa, P van der Harst, M Walker, H Wallaschofski, NJ Wareham, H Watkins, DR Weir, HE Wichmann, JF Wilson, P Zanen, IB Borecki, P Deloukas, CS Fox, IM Heid, JR O'Connell, DP Strachan, K Stefansson, CM van Duijn, GR Abecasis, L Franke, TM Frayling, MI McCarthy, PM Visscher, A Scherag, CJ Willer, M Boehnke, KL Mohlke, CM Lindgren, JS Beckmann, I Barroso, KE North, E Ingelsson, JN Hirschhorn, RJ Loos, EK Speliotes

TITLE:

Genetic studies of body mass index yield new insights for obesity biology.

JOURNAL:

Nature Feb 2015, Vol 518, pp. 197-206

ABSTRACT:

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. PUBMED: 25673413
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Annotation Information

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body mass index (EFO:0004340)

Gene List • 312 Genes

Genes in threshold: 312

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