DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Cisplatin-induced ototoxicity. The EFO term ototoxicity, response to cisplatin was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: ototoxicity, response to cisplatin

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

HE Wheeler, ER Gamazon, R Frisina, C Perez-Cervantes, O El Charif, B Mapes, SD Fossa, D Feldman, R Hamilton, DJ Vaughn, C Beard, C Fung, C Kollmannsberger, J Kim, T Mushiroda, M Kubo, S Ardeshir-Rouhani-Fard, LH Einhorn, N Cox, ME Dolan, L Travis

TITLE:

Variants in WFS1 and other Mendelian deafness genes are associated with cisplatin-associated ototoxicity.

JOURNAL:

Clinical cancer research : an official journal of the American Association for Cancer Research Dec 2016, Vol None, pp. None

ABSTRACT:

Cisplatin is one of the most commonly used chemotherapy drugs worldwide and one of the most ototoxic. We sought to identify genetic variants that modulate cisplatin-associated ototoxicity (CAO). PUBMED: 28039263
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