DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Multiple myeloma. The EFO term multiple myeloma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: multiple myeloma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

D Chubb, N Weinhold, P Broderick, B Chen, DC Johnson, A Försti, J Vijayakrishnan, G Migliorini, SE Dobbins, A Holroyd, D Hose, BA Walker, FE Davies, WA Gregory, GH Jackson, JA Irving, G Pratt, C Fegan, JA Fenton, K Neben, P Hoffmann, MM Nöthen, TW Mühleisen, L Eisele, FM Ross, C Straka, H Einsele, C Langer, E Dörner, JM Allan, A Jauch, GJ Morgan, K Hemminki, RS Houlston, H Goldschmidt

TITLE:

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.

JOURNAL:

Nature genetics Oct 2013, Vol 45, pp. 1221-5

ABSTRACT:

To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition. PUBMED: 23955597
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