DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Tumor biomarkers. The EFO term cancer biomarker measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: cancer biomarker measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M He, C Wu, J Xu, H Guo, H Yang, X Zhang, J Sun, D Yu, L Zhou, T Peng, Y He, Y Gao, J Yuan, Q Deng, X Dai, A Tan, Y Feng, H Zhang, X Min, X Yang, J Zhu, K Zhai, J Chang, X Qin, W Tan, Y Hu, M Lang, S Tao, Y Li, Y Li, J Feng, D Li, ST Kim, S Zhang, H Zhang, SL Zheng, L Gui, Y Wang, S Wei, F Wang, W Fang, Y Liang, Y Zhai, W Chen, X Miao, G Zhou, FB Hu, D Lin, Z Mo, T Wu

TITLE:

A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.

JOURNAL:

Gut Jan 2014, Vol 63, pp. 143-51

ABSTRACT:

Tumour biomarkers are used as indicators for cancer screening and as predictors for therapeutic responses and prognoses in cancer patients. We aimed to identify genetic loci that influence concentrations of cancer antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA) and α fetoprotein (AFP), and investigated the associations between the significant single nucleotide polymorphisms (SNPs) with risks of oesophageal squamous cell (OSCC), pancreatic and hepatocellular cancers. PUBMED: 23300138
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