DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy). The EFO term thoracic aortic aneurysm, Abdominal Aortic Aneurysm, brain aneurysm was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: thoracic aortic aneurysm, Abdominal Aortic Aneurysm, brain aneurysm

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

FN van 't Hof, YM Ruigrok, CH Lee, S Ripke, G Anderson, M de Andrade, AF Baas, JD Blankensteijn, EP Böttinger, MJ Bown, J Broderick, P Bijlenga, DS Carrell, DC Crawford, DR Crosslin, C Ebeling, JG Eriksson, M Fornage, T Foroud, M von Und Zu Fraunberg, CM Friedrich, EI Gaál, O Gottesman, DC Guo, SC Harrison, J Hernesniemi, A Hofman, I Inoue, JE Jääskeläinen, GT Jones, LA Kiemeney, R Kivisaari, N Ko, S Koskinen, M Kubo, IJ Kullo, H Kuivaniemi, MI Kurki, A Laakso, D Lai, SM Leal, H Lehto, SA LeMaire, SK Low, J Malinowski, CA McCarty, DM Milewicz, TH Mosley, Y Nakamura, H Nakaoka, M Niemelä, J Pacheco, PL Peissig, J Pera, L Rasmussen-Torvik, MD Ritchie, F Rivadeneira, AM van Rij, RL Santos-Cortez, A Saratzis, A Slowik, A Takahashi, G Tromp, AG Uitterlinden, SS Verma, SH Vermeulen, GT Wang, B Han, GJ Rinkel, PI de Bakker

TITLE:

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.

JOURNAL:

Journal of the American Heart Association Jul 2016, Vol 5, pp. None

ABSTRACT:

Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. PUBMED: 27418160
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