DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Dengue shock syndrome. The EFO term Dengue Hemorrhagic Fever was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Dengue Hemorrhagic Fever

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

CC Khor, TN Chau, J Pang, S Davila, HT Long, RT Ong, SJ Dunstan, B Wills, J Farrar, T Van Tram, TT Gan, NT Binh, le T Tri, le B Lien, NM Tuan, NT Tham, MN Lanh, NM Nguyet, NT Hieu, N Van N Vinh Chau, TT Thuy, DE Tan, A Sakuntabhai, YY Teo, ML Hibberd, CP Simmons

TITLE:

Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.

JOURNAL:

Nature genetics Oct 2011, Vol 43, pp. 1139-41

ABSTRACT:

Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out in an independent Vietnamese sample of 1,737 cases and 2,934 controls. SNPs at two loci showed genome-wide significant association with DSS. We identified a susceptibility locus at MICB (major histocompatibility complex (MHC) class I polypeptide-related sequence B), which was within the broad MHC region on chromosome 6 but outside the class I and class II HLA loci (rs3132468, P(meta) = 4.41 × 10(-11), per-allele odds ratio (OR) = 1.34 (95% confidence interval: 1.23-1.46)). We identified associated variants within PLCE1 (phospholipase C, epsilon 1) on chromosome 10 (rs3765524, P(meta) = 3.08 × 10(-10), per-allele OR = 0.80 (95% confidence interval: 0.75-0.86)). We identify two loci associated with susceptibility to DSS in people with dengue, suggesting possible mechanisms for this severe complication of dengue. PUBMED: 22001756
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