DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Parkinson's disease. The EFO term Parkinson's disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Parkinson's disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

CC Spencer, V Plagnol, A Strange, M Gardner, C Paisan-Ruiz, G Band, RA Barker, C Bellenguez, K Bhatia, H Blackburn, JM Blackwell, E Bramon, MA Brown, MA Brown, D Burn, JP Casas, PF Chinnery, CE Clarke, A Corvin, N Craddock, P Deloukas, S Edkins, J Evans, C Freeman, E Gray, J Hardy, G Hudson, S Hunt, J Jankowski, C Langford, AJ Lees, HS Markus, CG Mathew, MI McCarthy, KE Morrison, CN Palmer, JP Pearson, L Peltonen, M Pirinen, R Plomin, S Potter, A Rautanen, SJ Sawcer, Z Su, RC Trembath, AC Viswanathan, NW Williams, HR Morris, P Donnelly, NW Wood

TITLE:

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.

JOURNAL:

Human molecular genetics Jan 2011, Vol 20, pp. 345-53

ABSTRACT:

We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS. Replication was attempted in an additional cohort of 1039 French PD cases and 1984 controls for the 27 regions showing the strongest evidence of association (P< 10(-4)). We replicated published associations in the 4q22/SNCA and 17q21/MAPT chromosome regions (P< 10(-10)) and found evidence for an additional independent association in 4q22/SNCA. A detailed analysis of the haplotype structure at 17q21 showed that there are three separate risk groups within this region. We found weak but consistent evidence of association for common variants located in three previously published associated regions (4p15/BST1, 4p16/GAK and 1q32/PARK16). We found no support for the previously reported SNP association in 12q12/LRRK2. We also found an association of the two SNPs in 4q22/SNCA with the age of onset of the disease. PUBMED: 21044948
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