DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Two-hour glucose challenge. The EFO term glucose tolerance test was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: glucose tolerance test

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

R Saxena, MF Hivert, C Langenberg, T Tanaka, JS Pankow, P Vollenweider, V Lyssenko, N Bouatia-Naji, J Dupuis, AU Jackson, WH Kao, M Li, NL Glazer, AK Manning, J Luan, HM Stringham, I Prokopenko, T Johnson, N Grarup, TW Boesgaard, C Lecoeur, P Shrader, J O'Connell, E Ingelsson, DJ Couper, K Rice, K Song, CH Andreasen, C Dina, A Köttgen, O Le Bacquer, F Pattou, J Taneera, V Steinthorsdottir, D Rybin, K Ardlie, M Sampson, L Qi, M van Hoek, MN Weedon, YS Aulchenko, BF Voight, H Grallert, B Balkau, RN Bergman, SJ Bielinski, A Bonnefond, LL Bonnycastle, K Borch-Johnsen, Y Böttcher, E Brunner, TA Buchanan, SJ Bumpstead, C Cavalcanti-Proença, G Charpentier, YD Chen, PS Chines, FS Collins, M Cornelis, G J Crawford, J Delplanque, A Doney, JM Egan, MR Erdos, M Firmann, NG Forouhi, CS Fox, MO Goodarzi, J Graessler, A Hingorani, B Isomaa, T Jørgensen, M Kivimaki, P Kovacs, K Krohn, M Kumari, T Lauritzen, C Lévy-Marchal, V Mayor, JB McAteer, D Meyre, BD Mitchell, KL Mohlke, MA Morken, N Narisu, CN Palmer, R Pakyz, L Pascoe, F Payne, D Pearson, W Rathmann, A Sandbaek, AA Sayer, LJ Scott, SJ Sharp, E Sijbrands, A Singleton, DS Siscovick, NL Smith, T Sparsø, AJ Swift, H Syddall, G Thorleifsson, A Tönjes, T Tuomi, J Tuomilehto, TT Valle, G Waeber, A Walley, DM Waterworth, E Zeggini, JH Zhao, T Illig, HE Wichmann, JF Wilson, C van Duijn, FB Hu, AD Morris, TM Frayling, AT Hattersley, U Thorsteinsdottir, K Stefansson, P Nilsson, AC Syvänen, AR Shuldiner, M Walker, SR Bornstein, P Schwarz, GH Williams, DM Nathan, J Kuusisto, M Laakso, C Cooper, M Marmot, L Ferrucci, V Mooser, M Stumvoll, RJ Loos, D Altshuler, BM Psaty, JI Rotter, E Boerwinkle, T Hansen, O Pedersen, JC Florez, MI McCarthy, M Boehnke, I Barroso, R Sladek, P Froguel, JB Meigs, L Groop, NJ Wareham, RM Watanabe

TITLE:

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.

JOURNAL:

Nature genetics Feb 2010, Vol 42, pp. 142-8

ABSTRACT:

Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 x 10(-17); ratio of insulin to glucose area under the curve, P = 1.3 x 10(-16)) and diminished incretin effect (n = 804; P = 4.3 x 10(-4)). We also identified variants at ADCY5 (rs2877716, P = 4.2 x 10(-16)), VPS13C (rs17271305, P = 4.1 x 10(-8)), GCKR (rs1260326, P = 7.1 x 10(-11)) and TCF7L2 (rs7903146, P = 4.2 x 10(-10)) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18)). PUBMED: 20081857
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