DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Amyotrophic lateral sclerosis. The EFO term amyotrophic lateral sclerosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: amyotrophic lateral sclerosis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M Deng, L Wei, X Zuo, Y Tian, F Xie, P Hu, C Zhu, F Yu, Y Meng, H Wang, F Zhang, H Ma, R Ye, H Cheng, J Du, W Dong, S Zhou, C Wang, Y Wang, J Wang, X Chen, Z Sun, N Zhou, Y Jiang, X Liu, X Li, N Zhang, N Liu, Y Guan, Y Han, Y Han, X Lv, Y Fu, H Yu, C Xi, D Xie, Q Zhao, P Xie, X Wang, Z Zhang, L Shen, Y Cui, X Yin, H Cheng, B Liang, X Zheng, TM Lee, G Chen, F Zhou, JH Veldink, W Robberecht, JE Landers, PM Andersen, A Al-Chalabi, C Shaw, C Liu, B Tang, S Xiao, J Robertson, F Zhang, LH van den Berg, L Sun, J Liu, S Yang, X Ju, K Wang, X Zhang

TITLE:

Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.

JOURNAL:

Nature genetics Jun 2013, Vol 45, pp. 697-700

ABSTRACT:

To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, Pcombined = 2.92 × 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, Pcombined = 2.35 × 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS. PUBMED: 23624525
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