DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Plasma plasminogen activator levels. The EFO term tissue plasminogen activator measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: tissue plasminogen activator measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

J Huang, JE Huffman, M Yamakuchi, M Yamkauchi, S Trompet, FW Asselbergs, M Sabater-Lleal, DA Trégouët, WM Chen, NL Smith, ME Kleber, SY Shin, DM Becker, W Tang, A Dehghan, AD Johnson, V Truong, L Folkersen, Q Yang, T Oudot-Mellkah, BM Buckley, JH Moore, FM Williams, H Campbell, G Silbernagel, V Vitart, I Rudan, GH Tofler, GJ Navis, A Destefano, AF Wright, MH Chen, AJ de Craen, BB Worrall, AR Rudnicka, A Rumley, EB Bookman, BM Psaty, F Chen, KL Keene, OH Franco, BO Böhm, AG Uitterlinden, AM Carter, JW Jukema, N Sattar, JC Bis, MA Ikram, MM Sale, B McKnight, M Fornage, I Ford, K Taylor, PE Slagboom, WL McArdle, FC Hsu, A Franco-Cereceda, AH Goodall, LR Yanek, KL Furie, M Cushman, A Hofman, JC Witteman, AR Folsom, S Basu, N Matijevic, WH van Gilst, JF Wilson, RG Westendorp, S Kathiresan, MP Reilly, RP Tracy, O Polasek, BR Winkelmann, PJ Grant, HL Hillege, F Cambien, DJ Stott, GD Lowe, TD Spector, JB Meigs, W Marz, P Eriksson, LC Becker, PE Morange, N Soranzo, SM Williams, C Hayward, P van der Harst, A Hamsten, CJ Lowenstein, DP Strachan, CJ O'Donnell

TITLE:

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

JOURNAL:

Arteriosclerosis, thrombosis, and vascular biology May 2014, Vol 34, pp. 1093-101

ABSTRACT:

Tissue plasminogen activator (tPA), a serine protease, catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for endogenous fibrinolysis. In some populations, elevated plasma levels of tPA have been associated with myocardial infarction and other cardiovascular diseases. We conducted a meta-analysis of genome-wide association studies to identify novel correlates of circulating levels of tPA. PUBMED: 24578379
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