DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Birth weight. The EFO term birth weight was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: birth weight

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M Horikoshi, H Yaghootkar, DO Mook-Kanamori, U Sovio, HR Taal, BJ Hennig, JP Bradfield, B St Pourcain, DM Evans, P Charoen, M Kaakinen, DL Cousminer, T Lehtimäki, E Kreiner-Møller, NM Warrington, M Bustamante, B Feenstra, DJ Berry, E Thiering, T Pfab, SJ Barton, BM Shields, M Kerkhof, EM van Leeuwen, AJ Fulford, Z Kutalik, JH Zhao, M den Hoed, A Mahajan, V Lindi, LK Goh, JJ Hottenga, Y Wu, OT Raitakari, MN Harder, A Meirhaeghe, I Ntalla, RM Salem, KA Jameson, K Zhou, DM Monies, V Lagou, M Kirin, J Heikkinen, LS Adair, FS Alkuraya, A Al-Odaib, P Amouyel, EA Andersson, AJ Bennett, AI Blakemore, JL Buxton, J Dallongeville, S Das, EJ de Geus, X Estivill, C Flexeder, P Froguel, F Geller, KM Godfrey, F Gottrand, CJ Groves, T Hansen, JN Hirschhorn, A Hofman, MV Hollegaard, DM Hougaard, E Hyppönen, HM Inskip, A Isaacs, T Jørgensen, C Kanaka-Gantenbein, JP Kemp, W Kiess, TO Kilpeläinen, N Klopp, BA Knight, CW Kuzawa, G McMahon, JP Newnham, H Niinikoski, BA Oostra, L Pedersen, DS Postma, SM Ring, F Rivadeneira, NR Robertson, S Sebert, O Simell, T Slowinski, CM Tiesler, A Tönjes, A Vaag, JS Viikari, JM Vink, NH Vissing, NJ Wareham, G Willemsen, DR Witte, H Zhang, J Zhao, JF Wilson, M Stumvoll, AM Prentice, BF Meyer, ER Pearson, CA Boreham, C Cooper, MW Gillman, GV Dedoussis, LA Moreno, O Pedersen, M Saarinen, KL Mohlke, DI Boomsma, SM Saw, TA Lakka, A Körner, RJ Loos, KK Ong, P Vollenweider, CM van Duijn, GH Koppelman, AT Hattersley, JW Holloway, B Hocher, J Heinrich, C Power, M Melbye, M Guxens, CE Pennell, K Bønnelykke, H Bisgaard, JG Eriksson, E Widén, H Hakonarson, AG Uitterlinden, A Pouta, DA Lawlor, GD Smith, TM Frayling, MI McCarthy, SF Grant, VW Jaddoe, MR Jarvelin, NJ Timpson, I Prokopenko, RM Freathy

TITLE:

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

JOURNAL:

Nature genetics Jan 2013, Vol 45, pp. 76-82

ABSTRACT:

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. PUBMED: 23202124
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