DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Triglycerides. The EFO term triglyceride measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: triglyceride measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

A Ko, RM Cantor, D Weissglas-Volkov, E Nikkola, PM Reddy, JS Sinsheimer, B Pasaniuc, R Brown, M Alvarez, A Rodriguez, R Rodriguez-Guillen, IC Bautista, O Arellano-Campos, LL Muñoz-Hernández, V Salomaa, J Kaprio, A Jula, M Jauhiainen, M Heliövaara, O Raitakari, T Lehtimäki, JG Eriksson, M Perola, KE Lohmueller, N Matikainen, MR Taskinen, M Rodriguez-Torres, L Riba, T Tusie-Luna, CA Aguilar-Salinas, P Pajukanta

TITLE:

Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.

JOURNAL:

Nature communications Jun 2014, Vol 5, pp. 3983

ABSTRACT:

Dyslipidemia and obesity are especially prevalent in populations with Amerindian backgrounds, such as Mexican-Americans, which predispose these populations to cardiovascular disease. Here we design an approach, known as the cross-population allele screen (CPAS), which we conduct prior to a genome-wide association study (GWAS) in 19,273 Europeans and Mexicans, in order to identify Amerindian risk genes in Mexicans. Utilizing CPAS to restrict the GWAS input variants to only those differing in frequency between the two populations, we identify novel Amerindian lipid genes, receptor-related orphan receptor alpha (RORA) and salt-inducible kinase 3 (SIK3), and three loci previously unassociated with dyslipidemia or obesity. We also detect lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5) harbouring specific Amerindian signatures of risk variants and haplotypes. Notably, we observe that SIK3 and one novel lipid locus underwent positive selection in Mexicans. Furthermore, after a high-fat meal, the SIK3 risk variant carriers display high triglyceride levels. These findings suggest that Amerindian-specific genetic architecture leads to a higher incidence of dyslipidemia and obesity in modern Mexicans. PUBMED: 24886709
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