DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Peak creatinine levels in vancomycin therapy. The EFO term response to vancomycin, serum creatinine measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: response to vancomycin, serum creatinine measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

SL Van Driest, TL McGregor, DR Velez Edwards, BR Saville, TE Kitchner, SJ Hebbring, M Brilliant, H Jouni, IJ Kullo, CB Creech, PJ Kannankeril, SI Vear, KB Brothers, EA Bowton, CM Shaffer, N Patel, JT Delaney, Y Bradford, S Wilson, LM Olson, DC Crawford, AL Potts, RH Ho, DM Roden, JC Denny

TITLE:

Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy.

JOURNAL:

PloS one None 2015, Vol 10, pp. e0127791

ABSTRACT:

Vancomycin, a commonly used antibiotic, can be nephrotoxic. Known risk factors such as age, creatinine clearance, vancomycin dose / dosing interval, and concurrent nephrotoxic medications fail to accurately predict nephrotoxicity. To identify potential genomic risk factors, we performed a genome-wide association study (GWAS) of serum creatinine levels while on vancomycin in 489 European American individuals and validated findings in three independent cohorts totaling 439 European American individuals. In primary analyses, the chromosome 6q22.31 locus was associated with increased serum creatinine levels while on vancomycin therapy (most significant variant rs2789047, risk allele A, β = -0.06, p = 1.1 x 10(-7)). SNPs in this region had consistent directions of effect in the validation cohorts, with a meta-p of 1.1 x 10(-7). Variation in this region on chromosome 6, which includes the genes TBC1D32/C6orf170 and GJA1 (encoding connexin43), may modulate risk of vancomycin-induced kidney injury. PUBMED: 26030142
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