DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Rheumatoid factor seropositivity in rheumatoid arthritis. The EFO term rheumatoid arthritis, rheumatoid factor seropositivity measurement, rheumatoid factor measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: rheumatoid arthritis, rheumatoid factor seropositivity measurement, rheumatoid factor measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

A Julià, F Blanco, B Fernández-Gutierrez, A González, JD Cañete, J Maymó, M Alperi-López, A Olivè, H Corominas, V Martínez-Taboada, I González-Álvaro, A Fernandez-Nebro, A Erra, S Sánchez-Fernández, A Alonso, M López-Lasanta, R Tortosa, L Codó, J Lluis Gelpi, AC García-Montero, J Bertranpetit, D Absher, RM Myers, J Tornero, S Marsal

TITLE:

Identification of IRX1 as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study.

JOURNAL:

Arthritis & rheumatology (Hoboken, N.J.) Jun 2016, Vol 68, pp. 1384-91

ABSTRACT:

Rheumatoid factor (RF) is a well-established diagnostic and prognostic biomarker in rheumatoid arthritis (RA). However, ∼20% of RA patients are negative for this anti-IgG antibody. To date, only variation at the HLA-DRB1 gene has been associated with the presence of RF. This study was undertaken to identify additional genetic variants associated with RF positivity. PUBMED: 26815016
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