DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Height. The EFO term body height was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body height

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

S Sanna, AU Jackson, R Nagaraja, CJ Willer, WM Chen, LL Bonnycastle, H Shen, N Timpson, G Lettre, G Usala, PS Chines, HM Stringham, LJ Scott, M Dei, S Lai, G Albai, L Crisponi, S Naitza, KF Doheny, EW Pugh, Y Ben-Shlomo, S Ebrahim, DA Lawlor, RN Bergman, RM Watanabe, M Uda, J Tuomilehto, J Coresh, JN Hirschhorn, AR Shuldiner, D Schlessinger, FS Collins, G Davey Smith, E Boerwinkle, A Cao, M Boehnke, GR Abecasis, KL Mohlke

TITLE:

Common variants in the GDF5-UQCC region are associated with variation in human height.

JOURNAL:

Nature genetics Feb 2008, Vol 40, pp. 198-203

ABSTRACT:

Identifying genetic variants that influence human height will advance our understanding of skeletal growth and development. Several rare genetic variants have been convincingly and reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2 are associated with variation in height in the general population. Here we report genome-wide association analyses, using genotyped and imputed markers, of 6,669 individuals from Finland and Sardinia, and follow-up analyses in an additional 28,801 individuals. We show that common variants in the osteoarthritis-associated locus GDF5-UQCC contribute to variation in height with an estimated additive effect of 0.44 cm (overall P < 10(-15)). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development. PUBMED: 18193045
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