DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Gallstone disease. The EFO term gallstones was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: gallstones

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

AD Joshi, C Andersson, S Buch, S Stender, R Noordam, LC Weng, PE Weeke, PL Auer, B Boehm, C Chen, H Choi, G Curhan, JC Denny, I De Vivo, JD Eicher, D Ellinghaus, AR Folsom, C Fuchs, M Gala, J Haessler, A Hofman, F Hu, DJ Hunter, HL Janssen, JH Kang, C Kooperberg, P Kraft, W Kratzer, W Lieb, PL Lutsey, S Darwish Murad, BG Nordestgaard, LR Pasquale, AP Reiner, PM Ridker, E Rimm, LM Rose, CM Shaffer, C Schafmayer, RM Tamimi, AG Uitterlinden, U Völker, H Völzke, Y Wakabayashi, JL Wiggs, J Zhu, DM Roden, BH Stricker, W Tang, A Teumer, J Hampe, A Tybjærg-Hansen, DI Chasman, AT Chan, AD Johnson

TITLE:

Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies.

JOURNAL:

Gastroenterology Aug 2016, Vol 151, pp. 351-363.e28

ABSTRACT:

A genome-wide association study (GWAS) of 280 cases identified the hepatic cholesterol transporter ABCG8 as a locus associated with risk for gallstone disease, but findings have not been reported from any other GWAS of this phenotype. We performed a large-scale, meta-analysis of GWASs of individuals of European ancestry with available prior genotype data, to identify additional genetic risk factors for gallstone disease. PUBMED: 27094239
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