DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Monocyte count. The EFO term monocyte count was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: monocyte count

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DR Crosslin, A McDavid, N Weston, X Zheng, E Hart, M de Andrade, IJ Kullo, CA McCarty, KF Doheny, E Pugh, A Kho, MG Hayes, MD Ritchie, A Saip, DC Crawford, PK Crane, K Newton, DS Carrell, CJ Gallego, MA Nalls, R Li, DB Mirel, A Crenshaw, DJ Couper, T Tanaka, FJ van Rooij, MH Chen, AV Smith, NA Zakai, Q Yango, M Garcia, Y Liu, T Lumley, AR Folsom, AP Reiner, JF Felix, A Dehghan, JG Wilson, JC Bis, CS Fox, NL Glazer, LA Cupples, J Coresh, G Eiriksdottir, V Gudnason, S Bandinelli, TM Frayling, A Chakravarti, CM van Duijn, D Melzer, D Levy, E Boerwinkle, AB Singleton, DG Hernandez, DL Longo, JC Witteman, BM Psaty, L Ferrucci, TB Harris, CJ O'Donnell, SK Ganesh, EB Larson, CS Carlson, GP Jarvik

TITLE:

Genetic variation associated with circulating monocyte count in the eMERGE Network.

JOURNAL:

Human molecular genetics May 2013, Vol 22, pp. 2119-27

ABSTRACT:

With white blood cell count emerging as an important risk factor for chronic inflammatory diseases, genetic associations of differential leukocyte types, specifically monocyte count, are providing novel candidate genes and pathways to further investigate. Circulating monocytes play a critical role in vascular diseases such as in the formation of atherosclerotic plaque. We performed a joint and ancestry-stratified genome-wide association analyses to identify variants specifically associated with monocyte count in 11 014 subjects in the electronic Medical Records and Genomics Network. In the joint and European ancestry samples, we identified novel associations in the chromosome 16 interferon regulatory factor 8 (IRF8) gene (P-value = 2.78×10(-16), β = -0.22). Other monocyte associations include novel missense variants in the chemokine-binding protein 2 (CCBP2) gene (P-value = 1.88×10(-7), β = 0.30) and a region of replication found in ribophorin I (RPN1) (P-value = 2.63×10(-16), β = -0.23) on chromosome 3. The CCBP2 and RPN1 region is located near GATA binding protein2 gene that has been previously shown to be associated with coronary heart disease. On chromosome 9, we found a novel association in the prostaglandin reductase 1 gene (P-value = 2.29×10(-7), β = 0.16), which is downstream from lysophosphatidic acid receptor 1. This region has previously been shown to be associated with monocyte count. We also replicated monocyte associations of genome-wide significance (P-value = 5.68×10(-17), β = -0.23) at the integrin, alpha 4 gene on chromosome 2. The novel IRF8 results and further replications provide supporting evidence of genetic regions associated with monocyte count. PUBMED: 23314186
Find other GeneSets from this publication