DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was QT interval. The EFO term QT interval was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: QT interval

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

A Pfeufer, S Sanna, DE Arking, M Müller, V Gateva, C Fuchsberger, GB Ehret, M Orrú, C Pattaro, A Köttgen, S Perz, G Usala, M Barbalic, M Li, B Pütz, A Scuteri, RJ Prineas, MF Sinner, C Gieger, SS Najjar, WH Kao, TW Mühleisen, M Dei, C Happle, S Möhlenkamp, L Crisponi, R Erbel, KH Jöckel, S Naitza, G Steinbeck, F Marroni, AA Hicks, E Lakatta, B Müller-Myhsok, PP Pramstaller, HE Wichmann, D Schlessinger, E Boerwinkle, T Meitinger, M Uda, J Coresh, S Kääb, GR Abecasis, A Chakravarti

TITLE:

Common variants at ten loci modulate the QT interval duration in the QTSCD Study.

JOURNAL:

Nature genetics Apr 2009, Vol 41, pp. 407-14

ABSTRACT:

The QT interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac death (SCD) when prolonged or shortened. A common variant in NOS1AP is known to influence repolarization. We analyze genome-wide data from five population-based cohorts (ARIC, KORA, SardiNIA, GenNOVA and HNR) with a total of 15,842 individuals of European ancestry, to confirm the NOS1AP association and identify nine additional loci at P < 5 x 10(-8). Four loci map near the monogenic long-QT syndrome genes KCNQ1, KCNH2, SCN5A and KCNJ2. Two other loci include ATP1B1 and PLN, genes with established electrophysiological function, whereas three map to RNF207, near LITAF and within NDRG4-GINS3-SETD6-CNOT1, respectively, all of which have not previously been implicated in cardiac electrophysiology. These results, together with an accompanying paper from the QTGEN consortium, identify new candidate genes for ventricular arrhythmias and SCD. PUBMED: 19305409
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