DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Colorectal cancer. The EFO term colorectal cancer was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: colorectal cancer

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

FR Schumacher, SL Schmit, S Jiao, CK Edlund, H Wang, B Zhang, L Hsu, SC Huang, CP Fischer, JF Harju, GE Idos, F Lejbkowicz, FJ Manion, K McDonnell, CE McNeil, M Melas, HS Rennert, W Shi, DC Thomas, DJ Van Den Berg, CM Hutter, AK Aragaki, K Butterbach, BJ Caan, CS Carlson, SJ Chanock, KR Curtis, CS Fuchs, M Gala, EL Giovannucc, EL Giocannucci, SM Gogarten, RB Hayes, B Henderson, DJ Hunter, RD Jackson, LN Kolonel, C Kooperberg, S Küry, S Kury, A LaCroix, CC Laurie, CA Laurie, M Lemire, M Lemire, D Levine, J Ma, KW Makar, C Qu, D Taverna, CM Ulrich, K Wu, S Kono, DW West, SI Berndt, S Bezieau, H Brenner, PT Campbell, AT Chan, J Chang-Claude, GA Coetzee, DV Conti, D Duggan, JC Figueiredo, BK Fortini, SJ Gallinger, WJ Gauderman, G Giles, R Green, R Haile, TA Harrison, M Hoffmeister, JL Hopper, TJ Hudson, E Jacobs, M Iwasaki, SH Jee, M Jenkins, WH Jia, A Joshi, L Li, NM Lindor, K Matsuo, V Moreno, B Mukherjee, PA Newcomb, JD Potter, L Raskin, G Rennert, S Rosse, G Severi, RE Schoen, D Seminara, XO Shu, ML Slattery, S Tsugane, E White, YB Xiang, BW Zanke, W Zheng, L Le Marchand, G Casey, SB Gruber, U Peters

TITLE:

Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

JOURNAL:

Nature communications Jul 2015, Vol 6, pp. 7138

ABSTRACT:

Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies. PUBMED: 26151821
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