DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Crohn's disease. The EFO term Crohn's disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Crohn's disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JC Barrett, S Hansoul, DL Nicolae, JH Cho, RH Duerr, JD Rioux, SR Brant, MS Silverberg, KD Taylor, MM Barmada, A Bitton, T Dassopoulos, LW Datta, T Green, AM Griffiths, EO Kistner, MT Murtha, MD Regueiro, JI Rotter, LP Schumm, AH Steinhart, SR Targan, RJ Xavier, C Libioulle, C Sandor, M Lathrop, J Belaiche, O Dewit, I Gut, S Heath, D Laukens, M Mni, P Rutgeerts, A Van Gossum, D Zelenika, D Franchimont, JP Hugot, M de Vos, S Vermeire, E Louis, LR Cardon, CA Anderson, H Drummond, E Nimmo, T Ahmad, NJ Prescott, CM Onnie, SA Fisher, J Marchini, J Ghori, S Bumpstead, R Gwilliam, M Tremelling, P Deloukas, J Mansfield, D Jewell, J Satsangi, CG Mathew, M Parkes, M Georges, MJ Daly

TITLE:

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

JOURNAL:

Nature genetics Aug 2008, Vol 40, pp. 955-62

ABSTRACT:

Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development. PUBMED: 18587394
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