DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Sudden cardiac arrest. The EFO term sudden cardiac arrest was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: sudden cardiac arrest

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DE Arking, MJ Junttila, P Goyette, A Huertas-Vazquez, M Eijgelsheim, MT Blom, C Newton-Cheh, K Reinier, C Teodorescu, A Uy-Evanado, N Carter-Monroe, KS Kaikkonen, ML Kortelainen, G Boucher, C Lagacé, A Moes, X Zhao, F Kolodgie, F Rivadeneira, A Hofman, JC Witteman, AG Uitterlinden, RF Marsman, R Pazoki, A Bardai, RW Koster, A Dehghan, SJ Hwang, P Bhatnagar, W Post, G Hilton, RJ Prineas, M Li, A Köttgen, G Ehret, E Boerwinkle, J Coresh, WH Kao, BM Psaty, GF Tomaselli, N Sotoodehnia, DS Siscovick, GL Burke, E Marbán, PM Spooner, LA Cupples, J Jui, K Gunson, YA Kesäniemi, AA Wilde, JC Tardif, CJ O'Donnell, CR Bezzina, R Virmani, BH Stricker, HL Tan, CM Albert, A Chakravarti, JD Rioux, HV Huikuri, SS Chugh

TITLE:

Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.

JOURNAL:

PLoS genetics Jun 2011, Vol 7, pp. e1002158

ABSTRACT:

Sudden cardiac death (SCD) continues to be one of the leading causes of mortality worldwide, with an annual incidence estimated at 250,000-300,000 in the United States and with the vast majority occurring in the setting of coronary disease. We performed a genome-wide association meta-analysis in 1,283 SCD cases and >20,000 control individuals of European ancestry from 5 studies, with follow-up genotyping in up to 3,119 SCD cases and 11,146 controls from 11 European ancestry studies, and identify the BAZ2B locus as associated with SCD (P = 1.8×10(-10)). The risk allele, while ancestral, has a frequency of ~1.4%, suggesting strong negative selection and increases risk for SCD by 1.92-fold per allele (95% CI 1.57-2.34). We also tested the role of 49 SNPs previously implicated in modulating electrocardiographic traits (QRS, QT, and RR intervals). Consistent with epidemiological studies showing increased risk of SCD with prolonged QRS/QT intervals, the interval-prolonging alleles are in aggregate associated with increased risk for SCD (P = 0.006). PUBMED: 21738491
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